USC improved to 60-19 in its all-time series with Arizona and has won nine of the last 10 meetings with the Wildcats including the last two straight.
The Trojans' victory over Arizona guarantees the team a .500 record, which makes USC eligible for selection into the NCAA postseason tournament.
USC's win snapped a four-match losing streak, which was the program's longest since a four-match streak that lasted from Oct. 3-17, 2009.
For the second straight match, USC had three players post double-doubles.
Junior OH Samantha Bricio finished with 20 kills and 12 digs for her 16th double-double this season (38th of her career).
Sophomore OH Ebony Nwanebu tallied 12 kills and 10 digs for her fifth double-double this season; also the fifth of her career.
Sophomore setter Alice Pizzasegola had 32 assists and 11 digs for her fourth double-double of the season; the fifth double-double of her career.
Sophomore libero Taylor Whittingham reached a new career mark with 33 digs. It was her second-career match over the 30-dig threshold and her 24th match of the season in double digits for digs. It was her 12th match with 20 digs or more this year.
Bricio moved up from ninth into sixth at USC for career attacks. She now has 3,720 and moved in front of Jessica Gysin (2006-09), Lonise Norfleet (1987-90), and Keao Burdine (2001-04). Bricio's 1,241 attacks this season rank her ninth in USC's single-season record books.
Bricio also earned her 567th point this season, which ties her own mark set in 2012 for most single-season points by a Trojan.
Whittingham moved four spots from 11th to seventh in USC's single-season record books for digs. She now has 514 and moved ahead of Natalie Hagglund (497 in 2010), Katie Haller (504 in 1992), and Alli Hillgren (508 in 2007 and 510 in 2009). Only All-American liberos Hagglund and Debora Seilhamer have had more digs in a single season than Whittingham has this year.