USC improved to 4-0 in all-time meetings with Creighton.
The Trojans maintained their unblemished record against the three tourney foes and improved to 13-0 overall.
The USC victory brings head coach Mick Haley just five wins from reaching his 400th at USC (395-98). It also puts the program at just eight wins from reaching the 1,000-win threshold.
The Trojans won their third straight match and claimed a victory over its second top-25 ranked opponent.
Whittingham finished with 27 digs and pushed her career digs total to 1,327 to move into seventh all-time in the USC record books. In the process, she went ahead of Jennifer Kessy (1995-98; 1,311 digs) and Samantha Bricio (2012-15; 1,318 digs).
Lanier produced her fourth double-double in five matches (her third consecutive such match) and finished with season-high marks of 21 kills, 17 digs, and 24.0 points.
Junior MB Jordan Dunn recorded new career highs with 11.0 points and eight kills.